Depression is the most common mental disorder, which makes it one of the world's leading causes of significant difficulties among adults. The rate of depression does not decrease over the years, so the prevention of depressive disorders or intervention in the early stages is very important. In order to better determine the factors associated with the occurrence of depression, the role of response styles to positive affect and fear of positive and negative evaluation in explaining depression was investigated in this study. There were 425 research participants, all students between the ages of 19 to 26. The results indicate that all variables are stistically significantly related. Furthermore, the fear of positive evaluation, fear of negative evaluation, positive rumination and dampening are significant predictors of depression. However, despite the compelling correlation among fear of positive evaluation with depression, the named factor does not represent a significant predictor of depression after the introduction of a positive affect response strategy in the model. Dampening and positive rumination have been shown to be complete mediators of this relationship. However, in the relationship between fear of negative evaluation and depression, positive rumination and dampening were only partial mediators. These results indicate the importance of cognitive emotional regulation of positive affect as well as two types of fear of evaluation in explaining depression.