The aim of the conducted research was to examine the effect of assessment of health status, social support and level of activity on the quality of life of elderly people. 193 respondents from the Istrian County, Primorje-Gorski Kotar County and Osijek County participated in the research, of which 59 were men and 134 were women, in the age range of 60 to 90 years (M = 75, SD = 8.55). The following measures were used in the research: questions about the respondents' demographic data, a questionnaire about the frequency of engaging in various activities, a questionnaire about health problems (a measure of health problems and a health scale), a multidimensional scale of perceived social support and a questionnaire about quality of life. In order to examine the contribution of the observed variables in explaining the variance of the overall quality of life, a hierarchical regression analysis was performed where the perception of health status, social support and activity levels were predictors. It was found that self-assessment of health status, perceived social support from family and friends as well as leisure activities related to personal well-being are significant predictors of quality of life in old age. Activities related to care and nursing did not prove to be a significant predictor of quality of life in elderly people. The obtained results confirm the importance of maintaining health, preserving a quality social network and greater participation in various activities in order to make the overall quality of life of elderly people as high as possible.