The aim of this study was to examine the relationship between anxiety and executive functions in individuals with irritable bowel syndrome and to examine whether healthy individual and individuals with irritable bowel syndrome differ in measures of anxiety and executive functioning. The research was conducted as part of the scientific project "Cognitive-affective and behavioral determinants of irritable bowel syndrome". Total of 189 subjects participated in research, with 105 (21 men and 84 women) subjects being diagnosed with irritable bowel syndrome and treated at the Clinical Hospital center of Rijeka and the Clinical Hospital Sveti Duh. The healthy sample consisted of 84 subjects (19 men and 65 women) who by age, gender, marital status, employment status and level of education approximately corresponded to the clinical sample. The examination took place in hospital centers, at universities (Faculty of Humanities and Social Sciences Rijeka, Faculty of Health Studies Rijeka, University Departments in Rijeka) and within the personal circles of examiners. The examination on the clinical sample was conducted in three parts: the first and third part consisted of completing a set of anxiety questionnaires and solving cognitive tasks on computer. Second part consisted of two week monitoring period using diary technique. Results showed that there was no significant difference in the number of successfully solved trials and in average time needed to make the first move between irritable bowel syndrome individuals and healthy participants. Also, no significant difference in average time to make the first move was found between individuals with irritable bowel syndrome with high and low levels of anxious thoughts. There was a significant difference in the level of anxiety between individuals with irritable bowel syndrome and healthy participants for trait anxiety, visceral anxiety and anxious thoughts, with irritable bowel syndrome group showing significantly higher levels on all three measures. The results also showed a negative correlation between the average time needed to make the first move and anxious thoughts in the irritable bowel syndrome group, even after controlling the effect of age. The research findings indicate significant difficulties in the psychological domain of functioning for individuals with irritable bowel syndrome, as well as need for further examination of their cognitive profile.